Our Capabilities

Our facilities, based in Sandwich (UK), host state-of-the-art equipment for solid form selection, process design, development, non-clinical scale-up and troubleshooting. Our team have a wealth of knowledge gained from over 150 years’ combined experience within the pharmaceutical industry, with broad-ranging expertise across active ingredient and formulation development, and having delivered a diverse range of projects and products from early phases to launch. Many of Particology’s services and skills are also applicable to fine chemicals industries, such as petrochemical, or food industries, and any organization interested in further understand the properties, stability and functional attributes of their materials.

Our Equipment

    • Solubility screening

    • Salt, co-crystal, hydrate and solvate screening

    • Polymorph screening inc. relative stability assessment

    • Powder X-ray diffraction, including at controlled temperature and relative humidity conditions

    • Differential Scanning Calorimetry

    • Thermogravimetric Analysis

    • Dynamic Vapour Sorption

    • Hot stage microscopy

    • Spectroscopic characterisation techniques including infrared (IR) and near infrared (NIR)

    • Solubility and metastable zone width curve measurement

    • Process design, optimisation and scale-up using automated lab reactors (1mL – 5L scale), targeting yield, efficiency, purity and desired physical properties

    • Particle engineering including wet and dry milling and advanced techniques such as spherical crystallization and co-processing

    • Process analytical technologies including Mettler Toledo’s FBRM™ and BlazeMetrics’ BlazeBasic™

    • Filtration and drying studies, including de-risking agglomeration, attrition, solid form and stability studies

    • Chemical and physical product characterisation including purity, residual solvents, solid form, polarised light microscopy, atomic force microscopy, particle size and shape, surface area, surface energy, flow and density

    • Particle size measurement including method development, validation and analytical method transfer exercises (AMTE) using dry or wet dispersion techniques

    • Particle shape distribution and agglomeration assessment

    • Polarised light microscopy

    • Atomic force microscopy

    • Surface area and porosity

    • Surface energy

    • Bulk, tapped and true density

    • Flow measurement

    • Formulation development, including compressibility and sticking propensity

    • Mechanical sieving

    • Granulation

    • Turbula blender

    • Tablet press

    • Hardness tester

    • Friability testing

    • Tensile strength testing

    • Disintegration testing

Interested in any of our services?

Contact Us